http://www.ncbi.nlm.nih.gov/genome/guide/HsChr17.shtml
Human Chr 17 Pubmed Entrez BLAST OMIM Taxonomy Structure Search Genbank Genemap'99 Locuslink MEDLINE OMIM Unigene Maps dbsts for Human Genome Resources Select a Chromosome: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y Mapviewer Chr 17 Locuslink Chr. 17 Loci Unigene Chr. 17 Clusters Mouse Homologies for Human Chr. 17 Chromosome 17 Disease Genes TP53: Tumor protein p53 is a DNA binding protein. Mutations in the DNA binding portion of this protein lead to an increased incidence of numerous tumor types. Individuals with germline mutations in_this gene have a cancer predisposition syndrome known_as Li Fraumeni syndrome. Some diseases associated with chromosome 17 mutations Breast_cancer 1 Canavan_disease Miller-Dieker Lissencephaly Neurofibromatosis type 1 TP53, Tumor Suppressor Gene See OMIM or Genes and Disease for additional examples and detailed information. OMIM Home_page OMIM Morbid Map Genes and Disease Cytogenetics Mitelman et_al. 5) have_cataloged recurrent chromosome aberrations associated with cancers. Chromosome 17 aberrations Sequencing Progress Euchromatic size: 92000 kb Finished sequence: 45668 kb Percent finished: 49.6%Number of contigs: 123 List contigs by size List contigs by position Sequencing is being coordinated by Washington University and the Whitehead Institute. Major contributions have come from: The Whitehead Institute STS Maps Map STSS Type Ref Genemap'99 1263 RH 1 Whitehead 447 YAC 2 Stanford 339 RH 3 Genethon 186 Link 4 References 1 Deloukas et_al. 1998). ) A physical map of 30,000 human genes. Science 282,744-746.2 Hudson et_al. 1995). ) An STS-based map of the human genome. Science 270,1945-1954.3 Stewart et_al. 1997). ) An STS-based radiation hybrid map of the human genome. Genome Res 7, 422-433.4 Dib, et_al. 1995). ) A comprehensive genetic map of the human genome based_on 5, 264 microsatellites. Nature 380,152-154.5 Mitelman, et_al. 1997). ) A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet Apr 15 Suppl. 417-474. Comments or Questions? Write to the NCBI Service Desk