http://www.ncbi.nlm.nih.gov/genome/guide/HsChr22.shtml
Human Chr 22 Pubmed Entrez BLAST OMIM Taxonomy Structure Search Genbank Genemap'99 Locuslink MEDLINE OMIM Unigene Maps dbsts for Human Genome Resources Select a Chromosome: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y Mapviewer Chr 22 Locuslink Chr. 22 Loci Unigene Chr. 22 Clusters Mouse Homologies for Human Chr. 22 Chromosome 22 Download the entire sequence! STS Maps Map STSS Type Ref Genemap'99 565 RH 2 Whitehead 274 YAC 3 Stanford 182 RH 4 Genethon 67 Link 5 Disease Genes Some diseases associated with chromosome 22 mutations Digeorge_syndrome Cat eye syndrome Ewing sarcoma Neurofibromatosis, type2 Velocardiofacial syndrome See OMIM or Genes and Disease for additional examples and detailed information. OMIM Home_page OMIM Morbid Map Genes and Disease Cytogenetics The Philadelphia chromosome--a reciprocal translocation between chromosomes 9 and 22--is a marker for chronic myelogenous leukemia and one of the first cancer-associated chromosome abnormalities ever described. The translocation event links the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. Mitelman et_al. 6) have_cataloged recurrent chromosome aberrations associated with cancers. Chromosome 22 aberrations Aberrations involving BCR Kirsch et_al. 7) have_mapped chromosome 22 BAC clones by FISH to be_used as a reagent set for cytogenetic studies. Chromosome 22 BAC Map Sequencing is Complete! Chromosome 22 is the smallest human chromosome and the first to be_declared finished, according_to a recent report by Dunham et_al. 1). For more in_depth information, see the 2 Dec 1999 issue of Nature: The following genome sequencing laboratories have_made major contributions to the sequencing of chromosome 22: The Sanger Center The University of Oklahoma Keio University Washington University Euchromatic size: 34,491 kb Finished sequence: 33,464 kb Percent finished: 97%Number of contigs: 12 List of contigs by size List of contigs by position DNA for the remaining gaps (all 150kb) was_sequenced not because it is unstable in commonly used cloning systems. References 1 Dunham et_al. 1999). ) The DNA sequence of human chromosome 22. Nature 402,489-495.2 Deloukas et_al. 1998). ) A physical map of 30,000 human genes. Science 282,744-746.3 Hudson et_al. 1995). ) An STS-based map of the human genome. Science 270,1945-1954.4 Stewart et_al. 1997). ) An STS-based radiation hybrid map of the human genome. Genome Res 7, 422-433.5 Dib, et_al. 1995). ) A comprehensive genetic map of the human genome based_on 5, 264 microsatellites. Nature 380,152-154.6 Mitelman, et_al. 1997). ) A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet Apr 15 Suppl. 417-474.7 Kirsch, et_al. A systematic, high-resolution linkage of the cytogenetic and physical maps of the human genome: The Cancer chromosome aberration project (Ccap. Submitted. Comments or Questions? Write to the NCBI Service Desk