http://www.ncbi.nlm.nih.gov/genome/guide/HsChr4.shtml
Human Chr 4 Pubmed Entrez BLAST OMIM Taxonomy Structure Search Genbank Genemap'99 Locuslink MEDLINE OMIM Unigene Maps dbsts for Human Genome Resources Select a Chromosome: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y Mapviewer Chr 4 Locuslink Chr. 4 Loci Unigene Chr. 4 Clusters Mouse Homologies for Human Chr. 4 Chromosome 4 Sequencing Progress Euchromatic size: 203000 kb Finished sequence: 168178 kb Percent finished: 82.8%Number of contigs: 229 List contigs by size List contigs by position Sequencing is being coordinated by Washington University and The Whitehead Institute. Major contributions have come from: Stanford Human Genome Center The Sanger Center The Whitehead Institute Washington University Japanse Found. Cancer Res STS Maps Map STSS Type Ref Genemap'99 1478 RH 1 Whitehead 919 YAC 2 Stanford 1243 RH 3 Genethon 280 Link 4 Cytogenetics Mitelman et_al. 5) have_cataloged recurrent chromosome aberrations associated with cancers. Chromosome 4 aberrations Disease Genes Huntington_disease is a neurodegenerative disorder affecting approximately 30,000 Americans. It was the first disorder localized to a chromosome using RFLP analysis. Brain Section from a patient with Huntington's_disease showing dilation of ventricles and atrophy of caudate nucleus . Image credit: Kevin Roth and Robert Schmidt, Washington University, St_louis, MO, USA. Some diseases associated with chromosome 4 mutations Huntington_disease Juvenile Periodontitis Wolf-Hirschhorn Syndrome Wolfram_syndrome See OMIM or Genes and Disease for additional examples and detailed information. OMIM Home_page OMIM Morbid Map Genes and Disease References 1 Deloukas et_al. 1998). ) A physical map of 30,000 human genes. Science 282,744-746.2 Hudson et_al. 1995). ) An STS-based map of the human genome. Science 270,1945-1954.3 Stewart et_al. 1997). ) An STS-based radiation hybrid map of the human genome. Genome Res 7, 422-433.4 Dib, et_al. 1995). ) A comprehensive genetic map of the human genome based_on 5, 264 microsatellites. Nature 380,152-154.5 Mitelman, et_al. 1997). ) A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet Apr 15 Suppl. 417-474. Comments or Questions? Write to the NCBI Service Desk