http://www.ncbi.nlm.nih.gov/genome/guide/HsChr7.shtml
Human Chr 7 Pubmed Entrez BLAST OMIM Taxonomy Structure Search Contigs dbsts Genbank Genemap '99 Locuslink MEDLINE OMIM Unigene for Human Genome Resources Select a Chromosome: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y Mapviewer Chr 7 Locuslink Chr. 7 Loci Unigene Chr. 7 Clusters Mouse Homologies for Human Chr. 7 Chromosome 7 Sequencing Progress Euchromatic size: 171000 kb Finished sequence: 156169 kb Percent finished: 91.3%Number of contigs: 66 List contigs by size List contigs by position Sequencing is being coordinated by the Washington University Genome Sequencing Center (GSC. Major contributions have come from: Washington University GSC U. Wash. Genome Center U. Wash. MSC Inst. Molecular_biology, Jena STS Maps Map STSS Type Ref Genemap'99 1594 RH 1 Whitehead 781 YAC 2 Stanford 647 RH 3 Genethon 272 Link 4 NHGRI 2150 YAC 5 Cytogenetics Mitelman et_al. 7) have_cataloged recurrent chromosome aberrations associated with cancers. Chromosome 7 aberrations Kirsch et_al. 8) have_mapped chromosome 7 BAC clones by FISH to be_used as a reagent set for cytogenetic studies. Chromosome 7 BAC Map Disease Genes A mutation in a gene on chromosome 7 is resonsible for Pendred syndrome (6). Model of human pendrin. A schematic representation of the human pendrin is_depicted based_on its predicted amino_acid sequence . Note the eleven putative transmembrane segments. The approximate positions of alterations caused by known Pendred-syndrome mutations are_indicated. Some diseases associated with chromosome 7 mutations Cystic_fibrosis Pallister -Hall Syndrome Pendred Syndrome Split Hand/Foot Malformation Type1 Williams-Beuren Syndrome See OMIM or Genes and Disease for additional examples and detailed information. OMIM Home_page OMIM Morbid Map Genes and Disease References 1 Deloukas et_al. 1998). ) A physical map of 30,000 human genes. Science 282,744-746.2 Hudson et_al. 1995). ) An STS-based map of the human genome. Science 270,1945-1954.3 Stewart et_al. 1997). ) An STS-based radiation hybrid map of the human genome. Genome Res 7, 422-433.4 Dib, et_al. 1995). ) A comprehensive genetic map of the human genome based_on 5, 264 microsatellites. Nature 380,152-154.5 Bouffard et_al. 1997) A physical map of human chromosome 7: an integrated YAC contig map with average STS spacing of 79 kb. Genome Res 7, 673-692.6 Everett et_al. 1997). Pendred syndrome is_caused by mutations in a putative sulphate transporter gene (PDS. Nat Genet 17,411-422.7 Mitelman, et_al. 1997). ) A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet Apr 15 Suppl. 417-474.8 Kirsch, et_al. A Systematic, high resolution linkage of the cytogenetic and physical maps of the human genome: The Cancer chromosome aberration project (Ccap) Submitted. Comments or Questions? Write to the NCBI Service Desk